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主要原著論文

  1. Yokoyama Y., Shinohara K., Kitamura N., Nakamura A., Onoue A., Tanaka K., Hirayama A., Aw W., Nakamura S., Ogawa Y., Fukuda S., Tsubota K., Watanabe M.  Metabolic Effects of Bee Larva-Derived Protein in Mice: Assessment of an Alternative Protein Source Foods. 2021 Nov 1;10(11):2642. doi: 10.3390/foods10112642 Affiliations expand PMID: 34828923 PMCID: PMC8624207.

  2. Kubota M., Kawashima M., Inoue S., Imada T., Nakamura S., Kubota S., Watanabe M., Takemura R., Tsubota K.  Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen. Scientific Reports 11(1). 2021 Dec. DOI:10.1038/s41598-021-85895-y.

  3. Kitamura N, Yokoyama Y, Nagano U, Hosoda S, Taworntawat T, Nakamura A, Ogawa Y, Tsubota K, Watanabe M. Iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways. Sci Rep. 2021 May 24, 11(1):10753. Doi:10.1038/s41598-021-89673-8. PMID:34031430.

  4. Nakamura A, Yokoyama Y, Tanaka K , Benegiamo  G, Hirayama  A, Zhu Q , Kitamura K, Sugizaki T, Morimoto K, Itoh H, Fukuda S, Auwerx J, Tsubota K, Watanabe M. Asperuloside improves obesity and Type 2 diabetes through modulation of gut microbiota and metabolic signaling. iScience. 2020 Sep.25; 23(9).10152. PMID:32932138. DOI: 10.1016/j.isci.2020.101522.

  5. Sponton CH, Hosono T, Taura J, Jedrychowski MP, Yoneshiro T, Wang Q, Takahashi M, Matsui Y, Ikeda K, Oguri Y, Tajima K, Shinoda K, Pradhan RN, Chen Y, Brown Z, Roberts LS, Ward CC, Taoka H, Yokoyama Y, Watanabe M, Karasawa H, Nomura DK, Kajimura S. The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication. EMBO Rep(2020)21:e49828. 21 July 2020. DOI: 10.15252/embr.201949828

  6. Yokoyama Y, Nakamura TJ, Yoshimoto K, Ijyuin H, Tachikawa N, Oda H, Shiraishi R, Shinohara K, Kumadaki K, Honda S, Nakamura A, Kitamura N, Tsubota K, Watanabe M.　 　A high-salt/high fat diet alters circadian locomotor activity and glucocorticoid synthesis in mice. PLoS One. 2020 May 21;15(5):e0233386. doi: 10.1371/journal.pone.0233386. eCollection 2020. PMID: 32437460

  7. Nakamura A, Zhu Q, Yokoyama Y, Kitamura N, Uchida S, Kumadaki K, Tsubota K, Watanabe M. Agaricus brasiliensis KA21 May Prevent Diet-Induced Nash Through Its Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Activities in the Liver.　Foods. 2019 Nov 4;8(11). pii: E546. doi: 10.3390/foods8110546.

  8. Nakamura A, Kitamura N, Yokoyama Y, Uchida S, Kumadaki K, Tsubota K, Watanabe M.　 Melon GliSODin® Prevents Diet-Induced NASH Onset by Reducing Fat Synthesis and Improving Liver Function.　Nutrients. 2019 Aug 1;11(8). pii: E1779. doi: 10.3390/nu11081779.

  9. Tanaka H, Imasato M, Yamazaki Y, Matsumoto K, Kunimoto K, Delpierre J, Meyer K, Zerial M, Kitamura N, Watanabe M, Tamura A, Tsukita S. Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice. J Hepatol. 2018 Dec;69(6):1308-1316. doi: 10.1016/j.jhep.2018.08.025.

  10. Mikó E, Vida A, Kovács T, Ujlaki G, Trencsényi G, Márton J, Sári Z, Kovács P, Boratkó A, Hujber Z, Csonka T, Antal-Szalmás P, Watanabe M, Gombos I, Csoka B, Kiss B, Vígh L, Szabó J, Méhes G, Sebestyén A, Goedert JJ, Bai P. Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness. Biochim Biophys Acta Bioenerg. 2018 Sep;1859(9):958-974. doi: 10.1016/j.bbabio.2018.04.002.

  11. Yamada S, Takashina Y, Watanabe M, Nagamine R, Saito Y, Kamada N, Saito H. Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice. Oncotarget. 2018 Jan 6;9(11):9925-9939. doi: 10.18632/oncotarget.24066. eCollection 2018 Feb 9.

  12. Ban N, Ozawa Y, Osada H, Lin JB, Toda E, Watanabe M, Yuki K, Kubota S, Apte RS, Tsubota K. Neuroprotective role of retinal SIRT3 against acute photo-stress. NPJ Aging Mech Dis. 2017 Dec 4;3:19.

  13. Saegusa N, Sarukawa S, Ohta K, Takamatsu K, Watanabe M, Sugino T, Nakagawa M, Akiyama Y, Kusuhara M, Kishi K, Inoue K. Sutureless microvascular anastomosis assisted by an expandable shape-memory alloy stent. PLoS One. 2017 Jul 24;12(7):e0181520. doi: 10.1371/journal.pone.0181520. eCollection 2017.

  14. Kusumoto Y, Irie J, Iwabu K, Tagawa H, Itoh A, Kato M, Kobayashi N, Tanaka K, Kikuchi R, Fujita M, Nakajima Y, Morimoto K, Sugizaki T, Yamada S, Kawai T, Watanabe M, Oike Y, Itoh H. Bile acid binding resin prevents fat accumulation through intestinal microbiota in high-fat diet-induced obesity in mice. Metabolism. 2017 Jun;71:1-6. doi: 10.1016/j.metabol.2017.02.011. Epub 2017 Feb 27.

  15. Morimoto K, Watanabe M, Sugizaki T, Irie J, Itoh H.　Intestinal Bile Acid Composition Modulates Prohormone Convertase 1/3 (PC1/3) Expression and Consequent GLP-1 Production in Male Mice.　Endocrinology. 2016 Mar;157(3):1071-81.

  16. Tagawa H, Irie J, Itoh A, Kusumoto Y, Kato M, Kobayashi N, Tanaka K, Morinaga R, Fujita M, Nakajima Y, Morimoto K, Sugizaki T, Kawano Y, Yamada S, Kawai T, Watanabe M, Itoh H. Bile acid binding resin improves hepatic insulin sensitivity by reducing cholesterol but not triglyceride levels in the liver. Diabetes Res Clin Pract. 2015 Jul;109(1):85-94. doi: 10.1016/j.diabres.2015.04.025. Epub 2015 Apr 21.

  17. Yokoyama Y, Barnard ND, Levin SM, Watanabe M. Vegetarian diets and glycemic control in diabetes: a systematic review and meta-analysis.　Cardiovascular Diagnosis Therapy. 2014 Oct;4(5):373-82. doi: 10.3978/j.issn.2223-3652.2014.10.04.

  18. Matsumoto K, Imasato M, Yamazaki Y, Tanaka H, Watanabe M, Eguchi H, Nagano H, Hikita H, Tatsumi T, Takehara T, Tamura A, Tsukita S. Claudin 2 deficiency reduces bile flow and increases susceptibility to cholesterol gallstone disease in mice. Gastroenterology. 2014 Nov;147(5):1134-45.e10. doi: 10.1053/j.gastro.2014.07.033. Epub 2014 Jul 25.

  19. Sano K, Kawashima M, Ito A, Inaba T, Morimoto K, Watanabe M, Tsubota K. Aerobic exercise increases tear secretion in type 2 diabetic mice. Invest Ophthalmol Vis Sci. 2014 May 29;55(7):4287-94. doi: 10.1167/iovs.13-13289. PMID: 24876288

  20. Sugizaki T, Watanabe M(Corresponding Author), Horai Y, Kaneko-Iwasaki N, Arita E, Miyazaki T, Morimoto K, Honda A, Irie J, Itoh H.  The Niemann-Pick C1 Like 1 (NPC1L1) inhibitor Ezetimibe improves metabolic disease via decreased Liver X Receptor (LXR) activity in liver of obese male mice.　Endocrinology.. 2014 Apr 28:en20132143. DOI: 10.1210/en.2013-2143.

  21. Morimoto M, Itoh H, Watanabe M(Corresponding Author). Developments in understanding bile acid metabolism. Expert Rev. Endocrinol Metab. 2013; 59-69. DOI: 10.1586/eem.12.75.

  22. Bouillon R, Carmeliet G, Lieben L, Watanabe M, Perino A, Auwerx J, Schoonjans K, Verstuyf A. Vitamin D and energy homeostasis-of mice and men.　Nature Rev Endocrinol. 2013 Nov 19. DOI: 10.1038/nrendo.2013.226.

  23. Matsuzaki J, Suzuki H, Tsugawa H, Watanabe M, Hossain S, Arai E, Saito Y, Sekine S, Akaike T, Kanai Y, Mukaisho KI, Auwerx J, Hibi T. Bile Acids Increase Levels of microRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis. Gastroenterology. 145(6):1300-1311. 2013 Dec. DOI: 10.1053/j.gastro.2013.08.008. 

  24. Kerr TA, Matsumoto Y, Matsumoto H, Xie Y, Hirschberger LL, Stipanuk MH, Anakk S, Moore DD, Watanabe M, Kennedy S, Davidson NO. Cysteine Sulfinic Acid Decarboxylase Regulation: A Role for FXR and SHP in Murine Hepatic Taurine Metabolism. Hepatology Research. 2014 Oct. DOI: 10.1111/hepr.12230.

  25. Ban N, Ozawa Y, Inaba T, Miyake S, Watanabe M, Shinmura K, Tsubota K. Light-dark condition regulates sirtuin mRNA levels in the retina. Exp Gerontol. 2013 ; May 3. pii: S0531-5565(13)00108-3.

  26. Kawashima M, Ozawa Y, Shinmura K, Inaba T, Nakamura S, Kawakita T, Watanabe M, Tsubota K. Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders. Exp Gerontol. 2013 Apr 12. pii: S0531-5565(13)00100-9.

  27. Mizuno Y, Ninomiya Y, Nakachi Y, Iseki M, Iwasa H, Akita M, Tsukui T, Shimozawa N, Ito C, Toshimori K, Nishimukai M, Hara H, Maeba R, Okazaki T, Alodaib AN, Al Amoudi M, Jacob M, Alkuraya FS, Horai Y, Watanabe M, Motegi H, Wakana S, Noda T, Kurochkin IV, Mizuno Y, Schönbach C, Okazaki Y. Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility. PLoS Genet. 2013;9(2):e1003286.

  28. Watanabe M(Corresponding Author), Morimoto M, Houten S, Kaneko-Iwasaki N, Sugizaki T, Horai Y, Mataki C, Sato H, Murahashi K, Arita E, Schoonjans K, Suzuki T, Itoh H and Auwerx J. Bile acid binding resin improves metabolic control through the induction of energy expenditure. PLoS ONE. 2012; 7(8): e38285. DOI: 10.1371/journal.pone.0038286.

  29. Harach T, Pols TW, Nomura M, Maida A, Watanabe M, Auwerx J, Schoonjans K. TGR5 potentiates GLP-1 secretion in response to anionic exchange resins.Nature. Sci Rep. 2012;　2: 430. DOI: 10.1038/srep00430.

  30. Kawashima M, Kawakita T, Inaba T, Okada N, Ito M, Shimmura S, Watanabe M, Shinmura K, Tsubota K. Dietary lactoferrin alleviates age-related lacrimal gland dysfunction in mice. PLoS ONE. 2012; 7(3): e33148.

  31. Ichikawa R, Takayama T, Yoneno K, Kamada N, Kitazume MT, Higuchi H, Matsuoka K, Watanabe M, Itoh H, Kanai T, Hisamatsu T, Hibi T. Bile acids induce monocyte differentiation toward IL-12 hypo-producing dendritic cells via a TGR5-dependent pathway. Immunology. 136 (2): 153-62. 2012 Jun. doi: 10.1111/j.1365-2567.2012.03554.x.

  32. Obama T, Nagaoka S, Akagi K, Kato R, Horiuchi N, Horai Y, Aiuchi T, Arata S, Yamaguchi T, Watanabe M, Itabe H. Dietary Cholesterol Reduces Plasma Triacylglycerol in Apolipoprotein E-Knockout Mice: Suppression of Lipin-1 and Lipin-2 in the Glycerol-3-Phosphate Pathway. PLoS ONE. 2011 ; 6 : e22917.

  33. Sobukawa H, Watanabe M, Kano R, Ito T, Onozaki M, Hasegawa A, Kamata H. In vitro algaecide effect of disinfectants on Prototheca zopfii genotypes 1 and 2. J Vet Med Sci. 2011 Nov;73(11):1527-9. doi: 10.1292/jvms.11-0256. Epub 2011 Jul 8. PMID: 21737962

  34. Watanabe M (Corresponding Author), Horai Y, Houten SM, Morimoto K, Sugizaki T, Arita E, Mataki C, Sato H, Tanigawara Y, Schoonjans K, Itoh H and Auwerx J. Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure. J Biol Chem. 2011; 286: 26913-26920. DOI: 10.1074/jbc.M111.248203.

  35. Anakk S, Watanabe M, Ochsner AS, McKenna NJ, Finegold MJ, and Moore DD. Combined deletion of FXR and SHP results in juvenile onset cholestasis and de novo induction of Cyp17A1. J Clin Invest. 2010 ; 121 : 86-95. doi: 10.1172/JCI42846.

  36. Tamura A, Hayashi H, Imasato M, Yamazaki Y, Hagiwara A, Wada M, Noda T, Watanabe M, Suzuki Y, and Tsukita S. Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine. Gastroenterology. 2011 ; 140:913-23. Doi: 10.1053/j.gastro.2010.08.006.

  37. Nakatani H, Kasama K, Oshiro T, Watanabe M, Hirose H, Itoh H. Serum bile acid along with plasma incretins and serum high-molecular weight adiponectin levels are increased after bariatric surgery. Metabolism. 2009 ; 58: 1400-1407. DOI: 10.1016/j.metabol.2009.05.006.

  38. Park YJ, Qatanani M, Chua SS, LaRey JL, Johnson SA, Watanabe M, Moore DD, Lee YK. Loss of Orphan Receptore Small Heterodimer Partner Sensitizes Mice to liver injury from obstructive cholestasis. Hepatology. 2008 ; 47: 1578-1586.

  39. Bai P, Houten SM, Huber A, Schreiber V, Watanabe M, Kiss B, de Murcia G, Auwerx J, Ménissier-de Murcia J. PARP-2 controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the RXR/PPARgamma heterodimer. J Biol Chem. 2007; 282: 37738-37746.

  40. Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature. 2006; 439: 484-489. DOI: 10.138/nature04330.

  41. Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J, Thomas G. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature. 2004; 431: 200-205. DOI: 10.1038/nature02866

  42. Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, Heyman RA, Moore DD, Auwerx J. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest. 2004; 113: 1408-1418. DOI: 10.1172/JCI21025 

  43. Fajas L, Annicotte JS, Miard S, Sarruf D, Watanabe M, Auwerx J. Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice. J Clin Invest. 2004; 113: 1288-1295.

  44. Mascrez B, Ghyselinck NB, Watanabe M, Annicotte JS, Chambon P, Auwerx J, Mark M. Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells. EMBO Rep. 2004; 5: 285-290. doi: 10.1038/sj.embor.7400094.

  45. Tanaka T, Yamamoto J, Iwasaki S, Asaba H, Hamura H, Ikeda Y, Watanabe M, Magoori K, Ioka RX, Tachibana K, Watanabe Y, Uchiyama Y, Sumi K, Iguchi H, Ito S, Doi T, Hamakubo T, Naito M, Auwerx J, Yanagisawa M, Kodama T, Sakai J. Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci U S A. 2003; 100: 15924-15929.

  46. Koutnikova H, Cock TA, Watanabe M, Houten SM, Champy MF, Dierich A, Auwerx J. Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. Proc Natl Acad Sci U S A. 2003; 100: 14457-14462.

  47. Picard F, Watanabe M, Schoonjans K, Lydon J, O'Malley BW, Auwerx J. Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation. Proc Natl Acad Sci U S A. 2002; 99: 15644-15648.

  48. Suzuki H, Watanabe M, Fujino T, Yamamoto T. Multiple promoters in rat acyl-CoA synthetase gene mediate differential expression of multiple transcripts with 5'-end heterogeneity. J Biol Chem. 1995; 270: 9676-9682.

  49. Schoonjans K, Watanabe M, Suzuki H, Mahfoudi M, Krey G, Wahli W, Grimaldi P, Staels B, Yamamoto T, Auwerx J.  Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J Biol Chem. 1995 Aug. 270(33);19269-76.

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